Neuroligin - 2 and the tightrope of excitation / inhibition balance in the 1 prefrontal cortex
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Neuroligin-2 and the tightrope of excitation/inhibition balance in the 1 prefrontal cortex 2 3 Liang J, Xu W, Hsu Y-T, Yee AX, Chen L, Südhof TC. Conditional neuroligin-2 knockout 4 in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive 5 impairments. Mol Psychiatry 20: 850-859, 2015. 6 7 Alice M.S. Durieux, Jamie Horder, Marija M. Petrinovic 8 9 Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, 10 Psychology and Neuroscience, King’s College London, De Crespigny Park, London SE5 11 8AF, UK 12
منابع مشابه
Neuro Forum Neuroligin-2 and the tightrope of excitation/inhibition balance in the prefrontal cortex
Durieux AM, Horder J, Petrinovic MM. Neuroligin-2 and the tightrope of excitation/inhibition balance in the prefrontal cortex. J Neurophysiol 115: 5–7, 2016. First published July 29, 2015; doi:10.1152/jn.00703.2015.—Excitation/inhibition imbalance is implicated in symptoms of neuropsychiatric disorders. We discuss a study by Liang et al. (Mol Psychiatry 20: 850–859, 2015) demonstrating that the...
متن کاملNeuroligin-2 and the tightrope of excitation/inhibition balance in the prefrontal cortex.
Excitation/inhibition imbalance is implicated in symptoms of neuropsychiatric disorders. We discuss a study by Liang et al. (Mol Psychiatry 20: 850-859, 2015) demonstrating that the conditional knockout of neuroligin-2, a postsynaptic adhesion protein, in the prefrontal cortex of adult mice results in alterations in inhibitory synaptic properties. However, behavioral impairments emerged prior t...
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تاریخ انتشار 2015